Research Grants for the Primary or Secondary Prevention of Opioid Overdose (R01)

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Opportunity ID:299896
Opportunity Number:RFA-CE-18-006
Opportunity Title:Research Grants for the Primary or Secondary Prevention of Opioid Overdose (R01)
Opportunity Category:Discretionary
Opportunity Category Explanation:
Funding Instrument Type:Grant
Category of Funding Activity:Health
Category Explanation:
CFDA Number(s):93.136
Eligible Applicants:State governments
County governments
City or township governments
Special district governments
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility”
Additional Information on Eligibility:
Agency Code:HHS-CDC-HHSCDCERA
Agency Name:Department of Health and Human Services
Centers for Disease Control and Prevention – ERA
Posted Date:Jan 08, 2018
Last Updated Date:Jan 08, 2018
Estimated Synopsis Post Date:Mar 01, 2018
Fiscal Year:2018
Award Ceiling:$500,000
Award Floor:$300,000
Estimated Total Program Funding:$6,000,000
Expected Number of Awards:4
Description:The awards pursuant to this Notice of Funding Opportunity are contingent upon the availability of funds. The Centers for Disease Control and Prevention’s National Center for Injury Prevention and Control (NCIPC) is soliciting investigator-initiated research that will help expand and advance our understanding about what works to prevent overdose from prescription and illicit opioids by developing and piloting, or rigorously evaluating novel primary or secondary prevention interventions. The intent of this Notice of Funding Opportunity (NOFO) is to: (1) build the scientific base for the primary or secondary prevention of opioid overdose, and (2) encourage collaboration of scientists from a spectrum of disciplines including public health, epidemiology, law enforcement, social work, economics, and criminal justice to perform research that can identify ways to prevent opioid overdose more effectively. NCIPC is soliciting investigator-initiated research that will help expand and advance our understanding about what works to prevent opioid overdose by developing and piloting, or rigorously evaluating novel primary or secondary prevention interventions. Interventions can be strategies, programs, or policies. Ultimately, this research is intended to improve state and local health departments’ ability to implement and improve interventions focused on preventing opioid-related deaths. Researchers are expected to develop and pilot, or rigorously evaluate novel primary or secondary prevention interventions that address prescription or illicit opioid overdose. Primary prevention approaches are expected to aim to prevent opioid misuse, abuse, and overdose before it occurs. Secondary prevention approaches are expected to focus on the more immediate responses to opioid overdose, such as emergency department services and linkage to treatment immediately following a nonfatal overdose. Clinical examinations of the treatment effectiveness for opioid use disorder are outside the scope of the objectives and will not be considered (e.g., studies that solely test the effectiveness of buprenorphine, methadone, or naltrexone). The key outcome of this research is to identify and determine the effectiveness of novel primary or secondary prevention interventions on prescription opioid overdose, illicit opioid overdose, or both. Many opioid overdose prevention strategies are implemented in states and communities without having been rigorously evaluated. In particular, strategies that appear to be promising that do not yet have rigorous evaluation data supporting them include strategies that 1) integrate public health and law enforcement efforts, enhance implementation of clinical practice guidelines, 2) link individuals with opioid use disorder to treatment such as through the use of peer navigators, 3) address social determinants such as jobs and housing that can serve as barriers to primary prevention strategies and recovery from opioid use disorder, and 4) involve employers for intervention delivery. It is anticipated that funded applicants will collaborate and partner with community and/or governmental organizations from multiple sectors (e.g., health, social services, law enforcement, criminal justice) that can provide access to populations at highest risk for opioid misuse and overdose and provide access to critical data systems. Investigators must provide information in the application demonstrating that they have an established relationship with each partner and a written agreement describing each partner’s role in the proposed research. To be considered eligible/responsive to this funding opportunity announcement, the application must include: Documentation that at least one member of the key personnel of the research team (the Project Director/Principal Investigator, Co-PD/Co-PI, or Co-Investigator), has expertise in the area of prescription or illicit substance use, abuse, or overdose prevention, as evidenced by at least one peer-reviewed publication in the area of substance abuse prevention or drug overdose prevention. Documentation of well-defined working relationships with all organizations (e.g., community organizations; state agencies controlling prescription drug monitoring data, coroner or medical examiner data, hospital data, insurance claims data) expected to participate in the research. This includes, but is not limited to relationships that will allow the investigators access to research population(s) or access to administrative data. The proposed research must 1) develop and pilot a new, innovative primary or secondary prevention intervention or 2) rigorously evaluate an existing, novel primary or secondary prevention intervention, focused on opioid overdose outcomes. Applications proposing only to conduct etiological research to examine the prevalence or correlates of behavior, or proposing development of an intervention without proposing piloting or evaluation of that intervention will be considered nonresponsive. Applications proposing to evaluate law enforcement or criminal justice responses without a strong public health component will be considered nonresponsive.
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