Understanding the Rules of Life: Microbiome Interactions and Mechanisms

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Funding Opportunity ID: 330041
Opportunity Number: 21-534
Opportunity Title: Understanding the Rules of Life: Microbiome Interactions and Mechanisms
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Science and Technology and other Research and Development
Category Explanation:
CFDA Number(s): 47.041
47.049
47.050
47.070
47.074
47.075
47.076
47.079
47.083
Eligible Applicants: Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility: *Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research labs, professional societies and similar organizations in the U.S. associated with educational or research activities. -Institutions of Higher Education (IHEs) – Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members.Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.
Agency Code: NSF
Agency Name: National Science Foundation
Posted Date: Nov 25, 2020
Close Date: Feb 23, 2021
Last Updated Date: Nov 25, 2020
Award Ceiling: $0
Award Floor: $0
Estimated Total Program Funding: $15,000,000
Expected Number of Awards: 8
Description: In 2016, the National Science Foundation (NSF) unveiled a set of "Big Ideas," 10 bold, long-term research and process ideas that identify areas for future investment at the frontiers of science and engineering (see https://www.nsf.gov/news/special_reports/big_ideas/index.jsp). The Big Ideas represent unique opportunities to position our Nation at the cutting edge of global science and engineering by bringing together diverse disciplinary perspectives to support convergence research. As such, when responding to this solicitation, even though proposals must be submitted to the Division of Emerging Frontiers in the Directorate for Biological Sciences (BIO/EF), once received, the proposals will be managed by a cross-disciplinary team of NSF Program Directors. Understanding the Rules of Life (URoL): PredictingPhenotypeis one of NSF’s 10 Big Ideas (https://www.nsf.gov/news/special_reports/big_ideas) and is focused on predicting the set of observable characteristics (phenotypes) based on the genetic makeup of the individual and the nature of its environment. The Understanding the Rules of Life: Microbiome Interactions and Mechanisms (URoL:MIM) program is an integrative collaborationacross several Directorates and Offices within the National Science Foundation. The objective of URoL:MIM is to understand interactions and mechanisms that govern the structure and function of microbiomes. By integrating the wide range of accumulated data and information on microbiome structure and function, new causal models of interactions and interdependencies across scales and systems can be generated. Elucidating these relationships will inform our understanding of the Rules of Life – the theoretical constructs and models that explain and predict the emergent characteristics of living systems, as seen in the robustness, resilience,and adaptability of the individual organisms, populations, and communities. We define a microbiome as a collection of different microbes in a specific habitat. This may include non-host-associated microbiomes andhost-associated microbiomes, such as those in humans and other organisms, where i) the microbiome impacts host physiology, behavior, development, and fitness; ii) the host influences the metabolic activity, dynamics and evolution of the microbiome, and iii) the environment (biological, chemical, physical, and social) influences and is influenced by both the host and the microbiome. TheURoL:MIM program invites integrated, interdisciplinary proposals that create new knowledge in multiple disciplines to develop causal frameworks with well-designed scientific and/or computational approaches to test hypotheses about the relationships within the microbiome, and among the microbiome, the host, and the environment. Projects may develop new computational, mathematical, or experimental tools, and models, to: i) explain function and interactions in natural, experimental, and model microbiomes; ii) elucidate the chemical and molecular mechanisms that underlie communication between the host and the microbiome and among the members of the microbiome; and/or iii) comparatively analyze characteristics of microbiomes to discover emergent properties that provide insight into the behavior of living systems. Successful projectswill contribute to a portfolio of research that identifies general principles ("rules") that underlie a wide spectrum of biological phenomena across different spatial, complexity (e.g., molecular, cellular, organismal, population), and/or temporal scales (from sub-second to geologic).URoL:MIM projects must be novel and innovative inmore than onediscipline (e.g.,biology, chemistry, computer science, engineering, geology, mathematics, physics, social and behavioral sciences).They must also incorporate best practices regarding protocol documentation, sample selection, data collection and analysis, as well as data sharing and accessibility. URoL:MIM projects must provide workforce development and/or innovative undergraduate or graduate education opportunities that increase the pipeline for MIM in higher education and train the next generation of microbiome scientists. Projects should benefit society through engagement of the public and/or enhancement of K-12 STEM education. URoL:MIM supports basic science research projects of different scales and scope. Projects may have a total budget of up to $3,000,000 and anaward duration of up to 5 years.
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