Pilot Centers for Precision Disease Modeling (U54)(Clinical Trials Not Allowed)


Funding Opportunity ID: 323538
Opportunity Number: PAR-20-085
Opportunity Title: Pilot Centers for Precision Disease Modeling (U54)(Clinical Trials Not Allowed)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:
CFDA Number(s): 93.351
Eligible Applicants: State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Agency Code: HHS-NIH11
Agency Name: Department of Health and Human Services
National Institutes of Health
Posted Date: Jan 08, 2020
Close Date: Mar 24, 2020
Last Updated Date: Jan 08, 2020
Award Ceiling: $1,250,000
Award Floor: $0
Estimated Total Program Funding: $4,000,000
Expected Number of Awards: 2
Description: This Funding Opportunity Announcement (FOA) invites U54 cooperative agreement applications for Pilot Centers for Precision Disease Modeling. The goal of the Centers is to support collaborative research projects that link current personalized medicine efforts in human subjects with advances in animal genomics and technologies for genetic manipulation and creation of interspecies somatic hybrids. Functionally linking these areas of research will produce programs to enhance the predictive value of preclinical studies based on the use of precision animal models. Centers will create a process by which the research community can nominate unique human genomic variants for a cost effective high-throughput testing in an animal model pipeline. After validation of the expected gene editing, the Centers will establish assays to conduct comprehensive functional and phenotyping analysis to evaluate disease-causing variants. An important mission of the Centers will be the creation and distribution of precision animal model resources and related services to the biomedical community. Therefore, Centers will establish pipelines for preclinical scientific discovery, disease modeling, and development of interventions based on innovative animal models. Because these preclinical pipelines eventually will be an integral part of diagnostics, care and therapeutic treatment of patients, Centers should demonstrate how they intend to achieve this. Even though the Centers will work on a limited number of focused projects, it is expected that the program and pipeline(s) developed by the Center will maintain multifaceted research activities to build core model systems that can be adjusted as required to accommodate a broad spectrum of diseases.
Version: 2
Modification Comments: updated Expiration date

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