Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43)

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Funding Opportunity ID: 297097
Opportunity Number: RFA-ES-17-008
Opportunity Title: Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Environment
Health
Category Explanation:
CFDA Number(s): 93.113
Eligible Applicants: Small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Agency Code: HHS-NIH11
Agency Name: Department of Health and Human Services
National Institutes of Health
Posted Date: Sep 05, 2017
Close Date: Jan 12, 2018
Last Updated Date: Sep 05, 2017
Award Ceiling:
Award Floor:
Estimated Total Program Funding: $2,000,000
Expected Number of Awards:
Description: This Funding Opportunity Announcement (FOA) supports Phase I (R43) and Fast Track (R44) Small Business Innovative Research (SBIR) grant proposals from small businesses concerns (SBCs) to develop novel, physiologically-relevant in vitro screening systems (e.g., engineered 3-dimensional or organotypic models) using cells derived from animal species typically utilized for toxicological testing, which will replicate biological interactions and toxicological responses observed in animal tissues or organs, will produce assay data suitable for comparisons between in vitro and in vivo animal toxicology studies, and may ultimately provide alternative methods to reduce the use of animals in toxicity testing. These systems will provide the improved understanding of biological processes and mechanisms of toxicity, and produce relevant data for alternative chemical exposure assessment methods to reduce animal testing.
Version: Synopsis 1





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