Notice of Intent to Publish a Funding Opportunity Announcement for Coordinating and Data Management Center for Translational and Basic Science Research in Early Lesions (TBEL) (U24 Clinical Trial Not Allowed)

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Opportunity ID:333298
Opportunity Number:NOT-CA-21-061
Opportunity Title:Notice of Intent to Publish a Funding Opportunity Announcement for Coordinating and Data Management Center for Translational and Basic Science Research in Early Lesions (TBEL) (U24 Clinical Trial Not Allowed)
Opportunity Category:Discretionary
Opportunity Category Explanation:
Funding Instrument Type:Cooperative Agreement
Category of Funding Activity:Health
Category Explanation:
CFDA Number(s):93.395
93.396
Eligible Applicants:State governments
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Additional Information on Eligibility:
Agency Code:HHS-NIH11
Agency Name:Department of Health and Human Services
National Institutes of Health
Posted Date:May 04, 2021
Last Updated Date:May 04, 2021
Estimated Synopsis Post Date:Jun 01, 2021
Fiscal Year:2022
Award Ceiling:$500,000
Award Floor:
Estimated Total Program Funding:
Expected Number of Awards:1
Description:The National Cancer Institute (NCI) intends to publish a Funding Opportunity Announcement (FOA) for the establishment of the Coordinating and Data Management Center (CDMC) for the Translational and Basic Science Research in Early Lesions (TBEL) Program. The TBEL program aims to integrate basic and translational cancer research concepts to examine the direct causal relationships and interactions of an early lesion, its microenvironment, and host-systemic factors as “co-organizers” of tumor initiation (or suppression) and malignant progression. The ultimate goals of the TBEL program are to further understand the biological and pathophysiological mechanisms driving or restraining precancers and early cancers and facilitate biology-backed precision prevention approaches. The responsibilities of the CDMC will be to (1) coordinate consortium-wide meetings and conferences, and cross-consortium collaborative activities; (2) provide statistical and computational analysis support; and (3) establish program data hub for data capture, curation and management, and protocol development and registration. The other scientific unit of the TBEL program will comprise the U54 Centers, which will be structured to efficiently bridge gaps between basic and translational research on early lesions and their microenvironments. This Notice is being provided to allow potential applicants sufficient time to develop a responsive TBEL Coordinating and Data Management Center application. Details of the planned pre-application webinar will be announced in the Guide after publication of the FOA. The companion notice for the TBEL U54 Centers is: NOT-CA-21-060. The FOA is expected to be published in Summer 2021 with an anticipated application due date in Fall 2021. The FOA will utilize the U24 Resource-Related Research Projects – Cooperative Agreements. Details of the planned FOA are provided below.
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