Notice of Intent to Publish a Funding Opportunity Announcement for Clinical Relevance of the Linkage between Environmental Toxicant Exposures and Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (R01 Clinical Trial Not Allowed)

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Opportunity ID:334932
Opportunity Number:NOT-NS-22-004
Opportunity Title:Notice of Intent to Publish a Funding Opportunity Announcement for Clinical Relevance of the Linkage between Environmental Toxicant Exposures and Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (R01 Clinical Trial Not Allowed)
Opportunity Category:Discretionary
Opportunity Category Explanation:
Funding Instrument Type:Grant
Category of Funding Activity:Health
Category Explanation:
CFDA Number(s):
Eligible Applicants:Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility:
Agency Code:HHS-NIH11
Agency Name:Department of Health and Human Services
National Institutes of Health
Posted Date:Jul 26, 2021
Last Updated Date:Jul 26, 2021
Estimated Synopsis Post Date:Jan 01, 2022
Fiscal Year:2022
Award Ceiling:$750,000
Award Floor:
Estimated Total Program Funding:$3,750,000
Expected Number of Awards:5
Description:The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on the clinical relevance of the linkage between environmental toxicant exposures and Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). There is consensus that environmental toxicants are a risk factor for AD/ADRD, but causality has been largely elusive. While human studies demonstrating an association of AD/ADRD with toxicant exposures are relatively abundant, there is a clear unmet need for more mechanistic research to support or refute the clinical relevance and the biological plausibility of an impact on disease initiation, progression, or modification. This is especially important for understanding the potentially modifiable causes of racial and socioeconomic inequities. The RFA will encourage neuroscientists and environmental health scientists to collaborate and conduct mechanistic AD/ADRD research on the actions of neurotoxicants on the nervous system. This Notice is being provided to allow potential applicants sufficient time to develop integrated multidisciplinary collaborations and responsive projects. The FOA is expected to be published in Winter 2022 with an expected application due date in Spring 2022. This FOA will utilize the R01 activity code.
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