Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium – Renal Analytic Core (U01 – Clinical Trial Not Allowed)

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Opportunity ID: 327567
Opportunity Number: NOT-DK-20-029
Opportunity Title: Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium – Renal Analytic Core (U01 – Clinical Trial Not Allowed)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:
CFDA Number(s):
Eligible Applicants: Public and State controlled institutions of higher education
Private institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility:
Agency Code: HHS-NIH11
Agency Name: Department of Health and Human Services
National Institutes of Health
Posted Date: Jun 08, 2020
Last Updated Date: Jun 08, 2020
Estimated Synopsis Post Date: Jul 15, 2020
Fiscal Year: 2021
Award Ceiling: $400,000
Award Floor:
Estimated Total Program Funding: $4,000,000
Expected Number of Awards: 1
Description: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Environmental Health Sciences (NIEHS) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite applications for research on Chronic Kidney Disease of Uncertain Etiology (CKDu) in Agricultural Communities. Included in this initiative will be a Renal Analytic Core to provide leadership in discovery science and support the analytic needs of the new consortium to study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE). The Renal Analytic Core will analyze blood and urine to assess renal function, analyze kidney biopsies, devise and carry out a scientific approach to understanding the cause or causes of CKDu, including planning a biological sampling strategy to be implemented at Field Sites. This collaborative research consortium will bring together a broad range of expertise and enable discovery science to understand the cause or causes of CKDu. The consortium will also work to identify potential therapeutic targets and public health interventions. The consortium will consist of a Scientific Data Coordinating Center, Field Sites, a Renal Analytic Core and the NIEHS Human Health Exposure Analysis Resource (HHEAR). The consortium will work together to develop common protocols for evaluation of participants who are currently affected with early manifestations of CKDu and controls, to define common strategies for biological sampling and environmental assessment, and to determine analytic strategies to best use the samples collected by the consortium. This FOA will not support intervention trials to prevent or treat CKDu. This FOA is intended to support only human studies and applications that include animal or model systems are not responsive . This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in Summer 2020 with an expected application due date in Fall 2020. This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.
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