Limited Competition: Pediatric Brain Tumor Consortium (UM1 Clinical Trials Required)

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Funding Opportunity ID: 320894
Opportunity Number: RFA-CA-19-059
Opportunity Title: Limited Competition: Pediatric Brain Tumor Consortium (UM1 Clinical Trials Required)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Education
Health
Category Explanation:
CFDA Number(s): 93.395
Eligible Applicants: Public and State controlled institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Member Sites as Foreign components are allowed only if they are Canadian institutions. See FOA for full eligibility details.
Agency Code: HHS-NIH11
Agency Name: Department of Health and Human Services
National Institutes of Health
Posted Date: Sep 23, 2019
Close Date: Nov 13, 2019
Last Updated Date: Sep 23, 2019
Award Ceiling: $3,300,000
Award Floor: $0
Estimated Total Program Funding: $4,000,000
Expected Number of Awards: 1
Description: This Funding Opportunity Announcement (FOA) is intended to continue support for the Pediatric Brain Tumor Consortium (PBTC). This Limited-Competition FOA solicits a single application from the current PBTC awardee. The PBTC was conceived as a dedicated clinical trials organization able to translate innovative therapies from the laboratory to early phase clinical testing so that treatment for primary brain tumors in children can be improved. The importance of the PBTC is highlighted by the continuing high mortality rate among some common brain tumors occurring in children [e.g., diffuse intrinsic pontine gliomas (DIPG), malignant supratentorial gliomas, and biologically high-risk medulloblastomas and ependymomas] and the functional impediments apparent in a large proportion of children surviving current therapies. The PBTC is designed to fill a unique niche in the NIH pediatric brain tumor research portfolio through its ability to translate multiple innovative therapies from the laboratory to early phase clinical testing.
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