From Genomic Association to Causation: A Convergent Neuroscience Approach to Linking Levels of Analysis for Understanding Neuropsychiatric Disorders (U19 Clinical Trial Optional)

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Funding Opportunity ID:329413
Opportunity Number:RFA-MH-21-165
Opportunity Title:From Genomic Association to Causation: A Convergent Neuroscience Approach to Linking Levels of Analysis for Understanding Neuropsychiatric Disorders (U19 Clinical Trial Optional)
Opportunity Category:Discretionary
Opportunity Category Explanation:
Funding Instrument Type:Cooperative Agreement
Category of Funding Activity:Health
Category Explanation:
CFDA Number(s):93.242
Eligible Applicants:State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility:Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Agency Code:HHS-NIH11
Agency Name:Department of Health and Human Services
National Institutes of Health
Posted Date:Oct 15, 2020
Close Date:Mar 17, 2021
Last Updated Date:Oct 15, 2020
Award Ceiling:$0
Award Floor:$0
Estimated Total Program Funding:
Expected Number of Awards:
Description:This Funding Opportunity Announcement (FOA) supports research to understand causal linkages across different scales (e.g., molecular, cellular, circuit, behavioral, clinical) relevant to neuropsychiatric disorders. The Convergent Neuroscience (CN) program goal is to establish theoretical models to show how specific constituent processes at one level of analysis contribute to quantifiable properties at other levels, either directly or as emergent phenomenon. Studies should incorporate four key features: (1) a premise on identifying the causal and disease-relevant relationships between objective genetic/biological/clinical criteria at two or more contiguous levels of analysis, whether involving human subjects or experimentally tractable in vivo or in vitro paradigms (genetic variation can be one of the contiguous levels of analysis or can be the context in which other, higher levels of analysis are linked); (2) use of the large and diverse datasets existing or generated at these levels of analysis to develop testable theoretical models within three years of award; (3) experimental testing of the model-based predictions to confirm or reject their validity, (4) preferential utilization of scalable approaches to maximize analytic throughput, content, sensitivity, selectivity, spatiotemporal resolution and robustness. Results should yield causal linkages between levels of analysis and mechanistically explain key functional dimension(s) relevant to mental illness pathophysiology. Leadership of research teams will include expertise in experimental neurobiology or clinical research paired with orthogonal theoretical disciplines (e.g., mathematics, computation, physics). This endeavor will be facilitated by active participation in a community-driven manner through the CN Consortium. Groups will manage their data and analysis methods using a harmonized framework with other U19 awardees through a CN Consortium Data Commons structure.
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