Eradication of Invasive Quagga and Zebra Mussels Using Engineered Disseminated Neoplasia

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Funding Opportunity ID: 317184
Opportunity Number: BOR-DO-19-N020
Opportunity Title: Eradication of Invasive Quagga and Zebra Mussels Using Engineered Disseminated Neoplasia
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Science and Technology and other Research and Development
Category Explanation:
CFDA Number(s): 15.560
Eligible Applicants: Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility: Biomilab, Inc.
Agency Code: DOI-BOR
Agency Name: Department of the Interior
Bureau of Reclamation
Posted Date: Jun 18, 2019
Close Date: Jun 27, 2019
Last Updated Date: Jun 18, 2019
Award Ceiling: $1,500,000
Award Floor: $1
Estimated Total Program Funding:
Expected Number of Awards: 1
Description: Under this Agreement, Biomilab, LLC. shall work to engineer normal quagga and zebra mussel hemocytes into “induced” DN cells (iDNCs) that can be used to transmit and foster lethal cancer into populations of these invasive species in open waters. Major tasks for the project include, but are not limited to: • Establish a facility for the maintenance of live zebra and quagga mussels • Determine methods and conditions for extended culture of explanted and dissociated mussel cells, and establish methods for their genetic modification • Determine methods for the transplantation/engraftment and survival of cultured cells to live mussels and complete characterization of target genes and gene products for use in genomic modification • Convert dreissenid mussel hemocytes to genetically-modified hemic disseminated neoplasia cells (iDNCs) and establishment of methods for long-term culture, expansion, and cryopreservation of iDNCs • Introduction of iDNCs to live quagga/zebra mussels and control mussels, and analysis of engraftment, dissemination, and toxicity
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